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PUBLICATIONS (since 2013)

Sobala LF, Speciale G, Zhu S, Raich L, Sannikova N, Thompson AJ, Hakki Z, Lu D, Shamsi Kazem Abadi S, Lewis AR, Rojas-Cervellera V, Bernardo-Seisdedos G, Zhang Y, Millet O, Jiménez-Barbero J, Bennet AJ, Sollogoub M, Rovira C, Davies GJ, Williams SJ. (2020) An Epoxide Intermediate in Glycosidase Catalysis. ACS Cent. Sci., 6, 760–770. Link

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Adabala PJP, Shamsi Kazem Abadi S, Akintola O, Bhosale S, Bennet AJ (2020) Conformationally Controlled Reactivity of Carbasugars Uncovers the Choreography of Glycoside Hydrolase Catalysis. J. Org. Chem., 85, 3336–3348. Link

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Shamsi Kazem Abadi S, Deen MC, Watson JN, Shidmoossavee FS, Bennet AJ (2020) Directed evolution of a remarkably efficient Kdnase from a bacterial neuraminidase. Glycobiology, 84, 325–333. Link

Ganga-Sah Y, Leznoff DB, Bennet AJ (2019) Synthesis of Sterically Congested 2,2'-Bi(Adamantyl)-Based Alcohol and Amines. J. Org. Chem., 84, 15276–15282. Link

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C. Colombo and A.J. Bennet (2019) The Physical Organic Chemistry of Glycopyranosyl Transfer Reactions in Solution and Enzyme-Catalyzed. Curr. Opin. Chem. Biol., 53, 145–157. Link

W. Ren, R. Pengelly, M. Farren-Dai, S. Shamsi Kazem Abadi, V. Oehler, O. Akintola, J. Draper, M. Meanwell, S. Chakladar, K. Åšwiderek, V. Moliner, R. Britton, T.M. Gloster and A.J. Bennet (2018)  Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level. Nat. Commun., 9, 3243. Link

S. Mohan, J.R. Thompson, B.M. Pinto and A.J. Bennet (2018)  Versatile Synthetic Route to Carbocyclic N-Acetylneuraminic Acid and its Derivatives. Tetrahedron, 38, 5213–5221. Link

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N. Sannikova, C.A.N. Gerak, F.S. Shidmoossavee, D.T. King, S. Shamsi Kazem Abadi, A.R. Lewis and A.J. Bennet (2018)  Both Chemical and Non-chemical Steps Limit the Catalytic Efficiency of Family 4 Glycoside Hydrolases. Biochemistry, 57, 3378–3386. Link

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C. Colombo, ÄŒ. Podlipnik, L.L. Presti, M. Niikura, A.J. Bennet and A. Bernardi (2018)  Design and Synthesis of Constrained Bicyclic Molecules as Candidate Inhibitors of Influenza A Neuraminidase. PLoS One, 13: e0193623. Link

J. Saunders, C. Adamson, Y. Ganga-Sah, A.R. Lewis and A.J. Bennet (2018)  Rearrangement and Nucleophilic Trapping of Bicyclo[4.1.0]hept-2-yl Derived Non-Classical Bicyclobutenium Ions. Can. J. Chem., 96, 235–240. Link

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J.R. Nesbitt, E.M.Y. Steves, C.R. Schonhofer, A. Cait, S. Manku, J.H.F. Yeung, A.J. Bennet, J.C. Choy, M.R. Hughes and M.M. Moore (2018)  The Aspergillus fumigatus Kdnase (sialidase) Contributes to Cell Wall Integrity and Virulence. Frontiers in Microbiology, 8, 2706. Link

C. Colombo and A.J. Bennet (2017)  Probing Transition State Analogy in Glycoside Hydrolase Catalysis. Adv. Phys. Org. Chem., 51C, 99–127. Link

M. Farren-Dai, J.R. Thompson, A. Bernardi, C. Colombo and A.J. Bennet (2017)  Observation of a tricyclic[4.1.0.02,4]heptane in a Michael addition-ring closure reaction and computational studies of its formation. J. Org. Chem., 82, 12511–12519. Link

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N. Sannikova, A.R. Lewis and A.J. Bennet (2017)  Measurement of Kinetic Isotope Effects by Continuously Monitoring Isotopologue Ratios Using NMR Spectroscopy. Method Enzymol., 596, 547–571. Link

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C.S. Carroll, C.L. Grieve, I. Murugathasan, A.J. Bennet, C.M. Czekster, H. Lui, J. Naismith and M.M. Moore (2017)  The rhizoferrin biosynthetic gene in the fungal pathogen Rhizopus delemar is a novel member of the NIS gene family. Int. J. Biochem. Cell Biol., 89, 136–146. Link

C. Adamson, R. Pengelly, S. Shamsi Kazem Abadi, S. Chakladar, J. Draper, R. Britton, T.M. Gloster and A.J. Bennet (2016)  Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl-Carbasugars. Angew. Chem. Int. Ed. Engl., 55, 14978–14982. Link

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A. Barlev, G.S. Sekhon, A.J. Bennet and D. Sen (2016)  DNA Photoreactivation by DNA: The UV1C DNAzyme Catalyzes Repair of Cyclobutane Thymine Dimers in DNA More Effectively Than Their de novo Formation. Biochemistry, 55, 6010–6018. Link

G. Speciale, M. Ferran-Dai, F.S. Shidmoossavee, S.J. Williams and A.J. Bennet (2016)  C2-Oxyanion Neighboring Group Participation: Transition State Structure for the Hydroxide-Promoted Hydrolysis of 4-Nitrophenyl alpha-D-Mannopyranoside. J. Am. Chem. Soc., 138, 14012–14019. Link

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C. Colombo, B.M. Pinto, A. Bernardi and A.J. Bennet (2016)  Synthesis and Evaluation of Influenza A Viral Neuraminidase Candidate Inhibitors Based on a Bicyclo[3.1.0]hexane Scaffold. Org. Biomol. Chem. 14, 6539–6553. Link

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N. Cekic, J.E. Heinonen, K.A. Stubbs, C. Roth, Y. He, A.J. Bennet, E.J. McEachern, G.J. Davies and D.J. Vocadlo (2016)  Analysis of Transition State Mimicry by Tight Binding Aminothiazoline Inhibitors Provides Insight into Catalysis by Human O-GlcNAcase. Chem. Sci., 7, 3742–3750. Link

K. Khazaei, J.H.F. Yeung, M.M. Moore and A.J. Bennet (2015)  Inhibitory Efficiencies for Mechanism-Based Inactivators of Sialidases. Can. J. Chem., 93, 1207–1213. Link

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J. Chan, A. Tang and A.J. Bennet (2015)  Transition-State Structure for the Hydronium Ion-Promoted Hydrolysis of alpha-D-Glucopyranosyl Fluoride. Can. J. Chem., 93, 463–467. Link

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S. Chakladar, Y. Wang, T. Clark, L. Cheng, S. Ko, D.J. Vocadlo and A.J. Bennet (2014)  A Mechanism-Based Inactivator of Glycoside Hydrolases Involving Formation of a Transient non-Classical Carbocation. Nat. Commun., 5, 5590. Link

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J. Chan, N. Sannikova, A. Tang and A.J. Bennet (2014)  Transition-State Structure for the Quintessential SN2 Reaction of a Carbohydrate: Reaction of alpha-Glucopyranosyl Fluoride with Azide Ion in Water. J. Am. Chem. Soc., 136, 12225–12228. Link

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L. Cheng, F.S. Shidmoossavee and A.J. Bennet (2014)  Neuraminidase Substrate Promiscuity Permits a Mutant Micromonospora viridifaciens Enzyme to Synthesize Artificial Carbohydrates. Biochemistry, 53, 3982–3989. Link

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S. Chakladar, S. Shamsi Kazem Abadi and A.J. Bennet (2014)  A Mechanistic Study on the α-N-Acetylgalactosaminidase from E. meningosepticum: A Family 109 Glycoside Hydrolase. MedChemComm., 5, 1188–1192. Link

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J.H. Yeung, J.C. Telford, F.S. Shidmoossavee, A.J. Bennet, G.L. Taylor and M.M. Moore (2013)  Kinetic and Structural Evaluation of Selected Active Site Mutants of the Aspergillus fumigatus KDNase (Sialidase). Biochemistry, 52, 9177–9186. Link 

F.S. Shidmoossavee, J.N. Watson and A.J. Bennet (2013)  Chemical Insight into the Emergence of Influenza Virus Strains that are Resistant to Relenza. J. Am. Chem. Soc., 135, 13254–13257. Link

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S. Shamsi Kazem Abadi, M. Tran, A.K. Yadav, P.J.P. Adabala, S. Chakladar and A.J. Bennet (2017)  New Class of Glycoside Hydrolase Mechanism-Based Covalent Inhibitors: Glycosylation Transition State Conformations. J. Am. Chem. Soc., 139, 10625–10628. Link

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